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There is evidence that IGF-I and its receptor are expressed in the myocardium and both aortic smooth muscle and endothelial cells[45, 147149], being all of them more sensitive to IGF-I than to insulin[150, 151]

What kills them off

doi:10.1172/JCI106182

Folate is released from the vesicles (or endosomes) into the cytosol, and the receptor protein rapidly recycles the vesicles back to the plasma membrane ( Figure 1 )